LINZESS is available in a once-daily dose for the following indications1

For IBS-C in 
adults | 290 mcg

LINZESS dosing tablet containers 290mcg

For IBS-C* ICD-10 Diagnosis Code

K58.12

For CIC in adults | 2 dosing options

LINZESS dosing tablet containers 145mcg

For CIC* ICD-10 Diagnosis Code

K59.042

For functional constipation 
in pediatric patients 6 to 17 years of age | 72 mcg

LINZESS dosing tablet containers 72mcg, 72mcg

For FC† ICD-10 Diagnosis Code

K59.042

Capsules shown not actual size. For adults with CIC, a dose of 72 mcg once daily may be used based on individual presentation or tolerability.

For informational purposes only. It is the responsibility of the healthcare provider to determine the appropriate code(s) for services provided to his or her patient. This information does not guarantee payment or coverage. Current as of April 2023.

*For adult patients.

† For pediatric patients 6 to 17 years of age.

CIC, chronic idiopathic constipation; FC, functional constipation; IBS-C, irritable bowel syndrome with constipation; ICD-10, International Classification of Diseases, Tenth Revision.

LINZESS should be taken1:

Every day

Once a day

On an empty stomach and at least 30 minutes prior to a meal

At approximately the same time each day

For patients who are unable to swallow the capsule whole, LINZESS capsules can be opened and administered orally with either applesauce or water1

Clinical considerations1

  • Duration of use is not limited
  • Dosing adjustments for patients with renal or hepatic impairment are not required
  • No drug-drug interactions are anticipated
  • Negligible systemic availability