LINZESS is available in a once-daily dose for the following indications1

Adult Indications

For 
adults with IBS-C: 290 mcg

LINZESS dosing tablet containers 290mcg

For adults with CIC
 2 dosing options:
145 mcg and 72 mcg


LINZESS dosing tablet containers 145mcg

Pediatric Indications

For IBS-C in pediatric patients 7 years of age and older:
145 mcg

LINZESS dosing tablet containers 290mcg

For FC in pediatric patients 6 years 
of age and older:
72 mcg


LINZESS dosing tablet containers 145mcg

For IBS-C* ICD-10 Diagnosis Code

K58.12,‡

For CIC* ICD-10 Diagnosis Code

K59.042,‡

For FC† ICD-10 Diagnosis Code

K59.042,‡

CIC, chronic idiopathic constipation; FC, functional constipation; IBS-C, irritable bowel syndrome with constipation; ICD-10, International Classification of Diseases, Tenth Revision.

For adults with CIC, a dose of 72 mcg once daily may be used based on individual presentation or tolerability.

*IBS-C indication applies to adults and pediatric patients 7 years of age and older; CIC indication applies to adults only.

†For pediatric patients 6 years of age and older.

‡For informational purposes only. It is the responsibility of the healthcare provider to determine the appropriate code(s) for services provided to his or her patient. This information does not guarantee payment or coverage. Current as of December 2025.

LINZESS should be taken1:

Every day

Once a day

On an empty stomach and at least 30 minutes prior to a meal

At approximately the same time each day

For patients who are unable to swallow the capsule whole, LINZESS capsules can be opened and administered orally with either applesauce or water1

Clinical considerations1

  • Duration of use is not limited
  • Dosing adjustments for patients with renal or hepatic impairment are not required
  • No drug-drug interactions are anticipated
  • Negligible systemic availability