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Functional constipation (6-17 years of age) mechanism of action

Not actual patients.

LINZESS increases fluid secretion and GI motility1-3,*

LINZESS is a peptide that stimulates the GC-C receptor1,3,*

LINZESS binds to the guanylate cyclase-C (GC-C) receptor resulting in an increase in intracellular & extracellular concentrations of cGMP, which stimulates secretion of chloride and bicarbonate into the intestinal lumen, resulting in increased intestinal fluid and accelerated transit.
LINZESS acts locally within the GI tract and has negligible 
systemic availability1

CFTR, cystic fibrosis transmembrane conductance regulator; cGMP, cyclic guanosine monophosphate; GC-C, guanylate cyclase-C; GI, gastrointestinal.

*Based on nonclinical studies. Systemic exposure of drug and active metabolite are negligible following oral administration.1

LINZESS activates GC-C receptors and stimulates secretion of electrolytes into the lumen of the intestine via activation of CFTR, which results in increased intestinal fluid content and accelerated transit.1