LINZESS increases fluid secretion and GI motility1-3,*
LINZESS is a peptide that stimulates the GC-C receptor1,3,*

CFTR, cystic fibrosis transmembrane conductance regulator; cGMP, cyclic guanosine monophosphate; GC-C, guanylate cyclase-C; GI, gastrointestinal.
*Based on nonclinical studies. Systemic exposure of drug and active metabolite are negligible following oral administration.1
†LINZESS activates GC-C receptors and stimulates secretion of electrolytes into the lumen of the intestine via activation of CFTR, which results in increased intestinal fluid content and accelerated transit.1